Levodopa effects on hand and speech movements in patients with Parkinsons disease: a FMRI study.Reportar como inadecuado

Levodopa effects on hand and speech movements in patients with Parkinsons disease: a FMRI study. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 ANTE-INSERM U836, équipe 5 - Neuro-imagerie fonctionnelle et métabolique GIN - Grenoble Institut des Neurosciences 2 INSERM U836, équipe 5, Neuroimagerie fonctionnelle et perfusion cérébrale GIN - Grenoble Institut des Neurosciences, Neuroradiologie & IRM 3 INSERM U836, équipe 11, Fonctions cérébrales et neuromodulation GIN - Grenoble Institut des Neurosciences 4 GIN - Grenoble Institut des Neurosciences 5 Département de neurologie 6 Neurologie C 7 CNC - Centre de neuroscience cognitive 8 Service de Neurologie des HUG 9 LPL - Laboratoire Parole et Langage

Abstract : Levodopa L-dopa effects on the cardinal and axial symptoms of Parkinson-s disease PD differ greatly, leading to therapeutic challenges for managing the disabilities in this patient-s population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both off and on levodopa L-dopa. Unilateral hand movements in the off medication state elicited brain activations in motor regions primary motor cortex, supplementary motor area, premotor cortex, cerebellum, as well as additional areas anterior cingulate, putamen, associative parietal areas; following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex M1, the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task off L-dopa, the cerebral activation profile was restricted to the right cerebellum hand movement, reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.

Autor: Audrey Maillet - Alexandre Krainik - Bettina Debû - Irène Troprès - Christelle Lagrange - Stéphane Thobois - Pierre Pollak -

Fuente: https://hal.archives-ouvertes.fr/


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