Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France.Reportar como inadecuado




Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 INVS - Institut de Veille Sanitaire 2 EPIET - European Programme for Intervention Epidemiology 3 EFS - Etablissement Français du Sang La Plaine Saint-Denis 4 Génétique moléculaire des virus à ARN 5 Centre National de Référence Virus Influenza Région Sud

Abstract : BACKGROUND: Knowledge of the age-specific prevalence of seroprotection and incidence of seroconversion infection is necessary to complement clinical surveillance data and statistical models.
It provides the basis for estimating the future impact of influenza A H1N1pdm09 and implementing appropriate prevention and response strategies.
METHODS: Using a cross-sectional design, two-stage stratified sampling and paired plasma samples, we estimated the age-specific prevalence of a protective level of H1N1pdm09 antibodies in the French adult population before and after the 2009-10 pandemic, and the proportion of those susceptible that seroconverted due to infection, from a single sample of 1,936 blood donors aged 20-70 years in mainland France in June 2010.
Samples with a haemagglutination inhibition HI titre ≥1∶40 were considered seropositive, and seroconversion due to infection was defined as a 4-fold increase in titre in the absence of H1N1pdm09 vaccination or pre-pandemic seropositivity.
RESULTS: Out of the 1,936 donors, 1,708 were included in the analysis.
Seroprevalence before the pandemic was 6.7% 95% CI 5.0, 8.9 with no significant differences by age-group p = 0.3.
Seroprevalence afterwards was 23.0% 95% CI 17.7, 29.3 with 20-29 year olds having a higher level than older groups p



Autor: Angie Bone - Jean-Paul Guthmann - Azzedine Assal - Dominique Rousset - Armelle Degeorges - Pascal Morel - Martine Valette - Vince

Fuente: https://hal.archives-ouvertes.fr/



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