en fr Feasibilty of Cancer Treatment in Elderly Patients Faisabilité des traitements anticancéreux chez les patients âgés en pratique courante. Reportar como inadecuado




en fr Feasibilty of Cancer Treatment in Elderly Patients Faisabilité des traitements anticancéreux chez les patients âgés en pratique courante. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1 CEpiA - Clinical Epidemiology and Ageing : Geriatrie Soins Primaires et Santé Publique

Abstract : INTRODUCTION. The incidence of cancer and mortality rises with age. Cancer treatment strategy is multimodal. In older patients, a geriatrician can perform a Comprehensive Geriatric Assessment CGA. This CGA can influence cancer treatment decision. The question of feasibility in elderly cancer patients is essential. Definition and measures of feasibility vary widely. Most previous studies focus only on one of the anticancer treatment modalities, mostly chemotherapy, without considering the other modalities. Analyse of feasibility is complexe because it’s a time dependant risk factor, a confounding factor and a mediating factor between the characteristics of the patients geriatric and oncology and prognosis.OBJECTIVESObjectives were to assess the frequency of treatment feasibility in real life in older patients with cancer and factors associated with feasibility, in particular the role of age taking into account together, the nature of the treatment, oncological and geriatric factors.METHODESWe analysed three cohorts: 1 ELCAPA ELderly Cancer Patient with cancer patients aged 70 years or older who are referred to geriatric oncology clinics for a CGA before cancer treatment 2 AGEVIM AGE-VessIe-chiMiothérapie with metastatic bladder cancer patients aged 70 years or older for whom a chemotherapy was decided 3 CORSAGE COlorectal canceRS, AGe and chemotherapy fEasibility with patients stage II or III colorectal cancer who started FOLFOX 6 regimen. We recorded feasibility of CT planned number of cycles, or no first cycle dose reduction or relative dose intensity >0.85, surgery patient alive 30 days after successfully performed planned surgical procedure, radiotherapy and hormonal therapy planned dose delivered. We conducted univariate and multivariate analyses to identify factors associated with treatment feasibilityRESULTSIn 385 patients of ELCAPA mean age, 80 years, overall feasibility rate was 86.8% for the group without metastases and almost 66% for the metastases group. For chemotherapy, feasibility was lowest respectively 70% and 60%. For others modalities, feasibility rates ranged from 100% to 85%. Factors independently associated with chemotherapy feasibility were good Performance Status PS < 2 p=0.002, good autonomy p=0.03, good renal function p=0.01 and not to be alone at home p=0.07. In 193 patients of AGEVIM mean age 75 years, rate of chemotherapy feasibility was 75%. Factors independently associated were decreasing age p=0.01, decreasing number of metastases p=0.01, and PS



Autor: Marie Laurent -

Fuente: https://hal.archives-ouvertes.fr/



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