Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men, homosexual men and women: prevalence and associated factors.Reportar como inadecuado




Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men, homosexual men and women: prevalence and associated factors. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Service d-hépato-gastro-entérologie 2 Département d-épidémiologie, biostatistique et recherche clinique 3 Service d-Anatomie et cytologie pathologique 4 Service des maladies infectieuses et tropicales 5 Modèles et méthodes de l-évaluation thérapeutique des maladies chroniques

Abstract : OBJECTIVE: To assess the prevalence of and factors associated with squamous intraepithelial lesions and condyloma human papillomavirus HPV-related lesions in HIV-infected patients. DESIGN: A cross-sectional study in a tertiary-care university hospital conducted in 516 consecutive outpatients. INTERVENTION: A systematic examination for macroscopic HPV-related lesions through anoscopy with histological confirmation, evaluation of dysplasia and HPV typing. Sexual behaviours were assessed using a semi-directive questionnaire. RESULTS: Of 473 patients examined, 200 homosexual men, 123 heterosexual men, 150 women, 108 23% had histologically confirmed anal HPV-related lesions 36, 15 and 11% of the respective populations, including 51 47% with only endoanal localization. Among these 108 patients, histological dysplasia of grades I or II and grade III were noted in 59 and two patients, respectively, invasive endoanal cancer in one; three patients also had high-risk oncogenicity HPV without dysplasia. Independent identified associated factors of HPV-related condyloma were the number of incidents of sexual intercourse per month odds ratio OR 1.04; 95% confidence interval CI 1.01-1.06, CD4 cell count below 200 x 10 cells-l OR 3.22; 95% CI 1.37-7.60, history of anal HPV lesion OR 4.57; 95% CI 2.13-9.81, and receptive anal intercourse OR 2.30; 95% CI 1.11-4.77. The two latter factors remained associated with histological dysplasia OR 2.82; 95% CI 1.38-5.76 for history of anal condyloma, and OR 4.29; 95% CI 2.18-8.44 for receptive anal intercourse. CONCLUSION: The high rate of condyloma and histological dysplasia seen argues for a systematic screening for these lesions in HIV-infected individuals.

keyword : HIV anal canal Human papillomavirus anal dysplasia anal cancer condyloma





Autor: Laurent Abramowitz - Dalila Benabderrahmane - Philippe Ravaud - Francine Walker - Christophe Rioux - Christine Jestin - Elisabeth

Fuente: https://hal.archives-ouvertes.fr/



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