Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus.Report as inadecuate

Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Department of Medicine - Unit of Anatomy 2 Neuroheuristic Research Group 3 The Schulich School of Medicine 4 Institute of Higher Nervous Activity and Neurophysiology 5 INSERM U836, équipe 7, Nanomédecine et cerveau GIN - Grenoble Institut des Neurosciences, Neuroheuristic Research Group

Abstract : Abnormal neuronal activity in the subthalamic nucleus STN plays a crucial role in the pathophysiology of Parkinson-s disease PD. In this study we investigated changes in rat STN neuronal activity after 28days following the injection of 6-OHDA in the substantia nigra pars compacta SNc. This drug provoked a lesion of SNc that induced a dopamine DA depletion assessed by changes in rotating capacity in response to apomorphine injection and by histological analysis. By means of extracellular recordings and waveshape spike sorting it was possible to analyze simultaneous spike trains and compute the crosscorrelations. Based on the analysis of the autocorrelograms we classified four types of firing patterns: regular Poissonian-like, oscillatory in the range 4-12Hz, bursty and cells characterized by a long refractoriness. The distribution of unit types in the control n=61 and lesioned n=83 groups was similar, as well as the firing rate. In 6-OHDA treated rats we observed a significant increase from 26% to 48% in the number of pairs with synchronous firing. These data suggest that the synchronous activity of STN cells, provoked by loss of DA cells in SNc, is likely to be among the most significant dysfunctions in the basal ganglia of Parkinsonian patients. We raise the hypothesis that in normal conditions, DA maintains a balance between funneling information via the hyperdirect cortico-subthalamic pathway and parallel processing through the parallel cortico-basal ganglia-subthalamic pathways, both of which are necessary for selected motor behaviors. This article is part of a Special Issue entitled -Neural Coding-.

keyword : Firing pattern Basal Ganglia 6-OHDA lesioned rats Parkinson-s disease

Author: Alessandra Lintas - Isabella Silkis - Lavinia Albéri - Alessandro Villa -



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