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* Corresponding author 1 Institute of Psychiatry, Psychology & Neuroscience, King-s College London 2 NEUROSPIN - Service NEUROSPIN 3 University of Edinburgh 4 Autism Research Centre and Section of Developmental Psychiatry 5 University Medical Center Utrecht 6 Universität Heidelberg Heidelberg 7 Medizinische Fakultät Mannheim 8 Radboud University Medical Center Nijmegen 9 Karolinska Institutet Stockholm 10 Génétique humaine et Fonctions cognitives 11 Università Campus Bio-Medico di Roma UCBM 12 UOR - University of Reading 13 Goethe-University Frankfurt am Main 14 pRED - Roche Pharma Research and Early Development Basel 15 F. Hoffmann-La Roche Basel 16 Uppsala University 17 Centre for Brain and Cognitive Development Birkbeck College 18 Icahn School of Medicine at Mount Sinai New York 19 University of Toronto 20 University of Cyprus Nicosia 21 Janssen Research & Development 22 University of Messina

Abstract : The EU-AIMS Longitudinal European Autism Project LEAP is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder ASD. The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers.

Abstract : From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms.

Abstract : The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive-impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive-impulsive ADHD symptoms than females.

Abstract : The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials.

Keywords : Heterogeneity IQ Phenotype Sex Age Autism Autism spectrum disorder Behaviours





Autor: Tony Charman - Eva Loth - Julian Tillmann - Daisy Crawley - Carolin Wooldridge - David Goyard - Jumana Ahmad - Bonnie Auyeung - S

Fuente: https://hal.archives-ouvertes.fr/



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