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* Corresponding author 1 Groupe de Recherche Sur Le Cancer du Poumon : Bases Moléculaires de la Progression Tumorale, Dépistage et Thérapie Génique 2 Recherche en épidémiologie et biostatistique 3 Immunopathologie de l-Inflammation 4 Service de pneumologie-allergologie 5 Service de pneumologie Lyon 6 School of Occupational & Environmental Hygiene 7 Département de médecine aiguë spécialisée 8 Service de Pneumologie Allergologie 9 Service de Pneumologie-Allergologie Hôpital de la Timone - APHM

Abstract : INTRODUCTION: EGEA Epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy, a case control and family study including 2048 individuals, was initiated to look for environmental and genetic risk factors for asthma. A synthesis of the results obtained since 2002 on phenotypic and environmental aspects of asthma severity and allergy are presented in this article. METHODS AND RESULTS: The results support a role for hormonal factors in asthma severity and in various allergic markers of asthma. A greater body mass index was related to a more severe asthma in women with early menarche. Associations between markers of allergy eosinophils, IgE and atopy and hormonal dependent events in women premenstrual asthma, menopause and oral contraceptive use have been found. In asthmatics, exposure to agents known to be associated with occupational asthma, active and passive smoking were associated with an increased clinical asthma severity score. The study underlines the protective role of country living and exposure to pets in early life on allergy markers in adulthood, supporting the hygiene hypothesis. CONCLUSIONS: New hypothesis will be tested in the near future from the second stage of this survey.

Mots-clés : Environnement asthme asthme sévère allergie

Autor: Valérie Siroux - Marie-Pierre Oryszczyn - Raphaëlle Varraso - Nicole Le Moual - Jean Bousquet - Denis Charpin - Frédéric Gorm

Fuente: https://hal.archives-ouvertes.fr/


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