Pneumopathie induite par lhydroxyurée. Hydroxyurea-induced pneumonia.Reportar como inadecuado

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* Corresponding author 1 Service de pneumologie 2 Service d-hématologie clinique 3 Service des urgences Rennes 4 Service de médecine interne 5 Contaminants Chimiques, immunité et Inflammation Irset - Institut de recherche, santé, environnement et travail Rennes, Service de pneumologie

Abstract : Introduction: Hydroxyurea is an antimetabolite widely used in the treatment of myeloproliferative diseases. Usual side effects are mainly hematological, gastrointestinal, neurological disorders and induced-fevers. More rarely, hydroxyurea-induced pneumonitis are reported. Case report: We report a case of a patient treated for polycythemia vera. She was admitted 20 days after introduction of hydroxyurea for a high fever, productive cough and clear sputum associated with nausea. Chest CT-scan found diffuse bilateral ground-glass opacities. The microbiological investigations were negative. Symptoms disappeared few days after discontinuation of treatment. Its reintroduction led to recurrence of symptoms. Conclusion: This additional case completes the 15 cases of hydroxyurea-induced pneumonitis described in the literature. Two forms of this disease seem to exist: an acute form with fever occurring in the month following introduction of hydroxyurea; and a chronic form without fever. Even if it is uncommon, pulmonologists should be aware of this complication.

Mots-clés : Pneumopathie médicamenteuse Fièvre Pneumopathie interstitielle Hydroxyurée

Autor: Anne Girard - Caroline Ricordel - Elsa Poullot - Valérie Claeyssen - Olivier Decaux - Benoît Desrues - Philippe Delaval - Stép



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