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Evidence-Based Complementary and Alternative MedicineVolume 2013 2013, Article ID 705315, 14 pages

Review Article

Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China

Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia

National Center for Design Measurement and Evaluation in Clinical Research, Guangzhou University of Chinese Medicine, Guangzhou 510405, China

Received 1 September 2012; Revised 29 November 2012; Accepted 19 January 2013

Academic Editor: Taixiang Wu

Copyright © 2013 Lei Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the efficacy and safety of oral Huangqiformulae for the treatment of stable COPD. Methods. The majordatabases were searched until September 2010 and supplemented witha manual search. Randomized controlled trials RCTs of oralHuangqi formulae that reported on lung function, St. George-sRespiratory Questionnaire, symptom improvement and-or frequency ofexacerbations were extracted by two reviewers. The Cochrane toolwas used for the assessment of risk of bias in the includedtrials. Data were analyzed with RevMan 5.1.2 software. Results. 25RCTs 1,661 participants were included. Compared withconventional therapy CT alone, oral Huangqi formulae plus CTincreased FEV1, and a similar result was found comparing Huangqiformulae with no treatment. Improvements in SGRQ total score,COPD-related symptoms and reduction of frequency of exacerbationswere found in patients receiving Huangqi formulae plus CT comparedto those receiving CT alone or CT plus placebo. No serious adverseevents were reported. However, there were some methodologicalinadequacies in the included studies. Conclusions. The benefits ofHuangqi formulae for stable COPD were promising, but its efficacyand safety have not been established due to methodologicalweakness and possible bias in the reported results. Furtherrigorously designed studies are warranted.





Autor: Lei Wu, Yuanbin Chen, Yinji Xu, Xinfeng Guo, Xiaoyan Li, Anthony Lin Zhang, Brian H. May, Charlie Changli Xue, Zehuai Wen,

Fuente: https://www.hindawi.com/



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