Mechanisms of Dyslipoproteinemias in Systemic Lupus ErythematosusReport as inadecuate

Mechanisms of Dyslipoproteinemias in Systemic Lupus Erythematosus - Download this document for free, or read online. Document in PDF available to download.

Clinical and Developmental Immunology - Volume 13 2006, Issue 2-4, Pages 203-208

Rheumatology Division, São Paulo University Medical School Hospital, São Paulo, SP, Brazil

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Autoimmunity and inflammation are associated with marked changes in lipid and lipoprotein metabolism in SLE. Autoantibodies and cytokines are able to modulate lipoprotein lipase LPL activity, a key enzyme in lipid metabolism, with a consequent “lupus pattern” of dyslipoproteinemia characterized by elevated levels of very low-density lipoprotein cholesterol VLDL and triglycerides TG and lower high-density lipoprotein cholesterol HDL levels. This pattern favors an enhanced LDL oxidation with a subsequent deleterious foam cell formation. Autoantibodies and immunocomplexes may aggravate this oxidative injury by inducing accumulation and deposition of oxLDL in endothelial cells. Drugs and associated diseases usually magnify the close interaction of these factors and further promote the proatherogenic environment of this disease.

Author: Eduardo F. Borba, Jozelio F. Carvalho, and Eloísa Bonfá



Related documents