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Behavioural Neurology - Volume 24 2011, Issue 1, Pages 3-10



Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, UK

Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK

Received 23 March 2011; Accepted 23 March 2011

Copyright © 2011 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alterations in consciousness are central to epileptic manifestations, and involve changes in both the level of awareness and subjective content of consciousness. Generalised seizures are characterised by minimal responsiveness and subjective experience whereas simple and complex partial seizures demonstrate more selective disturbances. Despite variations in ictal origin, behaviour and electrophysiology, the individual seizure types share common neuroanatomical foundations generating impaired consciousness. This article provides a description of the phenomenology of ictal consciousness and reviews the underlying shared neural network, dubbed the -consciousness system-, which overlaps with the -default mode- network. In addition, clinical and experimental models for the study of the brain correlates of ictal alterations of consciousness are discussed. It is argued that further investigation into both human and animal models will permit greater understanding of brain mechanisms and associated behavioural consequences, possibly leading to the development of new targeted treatments.





Autor: Andrea Eugenio Cavanna and Fizzah Ali

Fuente: https://www.hindawi.com/



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