No Polymorphism in Plasmodium falciparum K13 Propeller Gene in Clinical Isolates from Kolkata, IndiaReportar como inadecuado




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Journal of PathogensVolume 2015 2015, Article ID 374354, 4 pages

Research Article

Protozoology Unit, Department of Microbiology, Calcutta School of Tropical Medicine, 108 Chittaranjan Avenue, Kolkata 700 073, India

Department of Microbiology, NRS Medical College, 138 AJC Bose Road, Kolkata 700 014, India

Department of Zoology, APC Roy Government College, Himachal Bihar, Matigara, Siliguri, West Bengal 734 010, India

Department of Zoology, Ballygunge Science College, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, India

Calcutta School of Tropical Medicine, 108 Chittaranjan Avenue, Kolkata 700 073, India

Department of Tropical Medicine, Calcutta School of Tropical Medicine, 108 Chittaranjan Avenue, Kolkata 700 073, India

Received 19 August 2015; Accepted 11 November 2015

Academic Editor: Mariela A. Segura

Copyright © 2015 Moytrey Chatterjee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Molecular markers associated with artemisinin resistance in Plasmodium falciparum are yet to be well defined. Recent studies showed that polymorphisms in K13 gene are associated with artemisinin resistance. The present study was designed to know the pattern of polymorphisms in propeller region of K13 gene among the clinical isolates collected from urban Kolkata after five years of ACT implementation. We collected 59 clinical isolates from urban Kolkata and sequenced propeller region of K13 gene in 51 isolates successfully. We did not find any mutation in any isolate. All patients responded to the ACT, a combination of artesunate + sulphadoxine-pyrimethamine. The drug regimen is still effective in the study area and there is no sign of emergence of resistance against artemisinin as evidenced by wild genotype of K13 gene in all isolates studied.





Autor: Moytrey Chatterjee, Swagata Ganguly, Pabitra Saha, Biswabandhu Bankura, Nandita Basu, Madhusudan Das, Subhasish K. Guha, an

Fuente: https://www.hindawi.com/



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