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Infectious Diseases in Obstetrics and Gynecology - Volume 10 2002, Issue 2, Pages 93-96

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Box 3967, Durham, NC 27710, USA

Division of Neonatal Medicine, , Department of Pediatrics, Duke University Medical Center, Durham, NC, USA

Received 14 September 2001; Accepted 28 December 2001

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: The balance between cell survival and cell death apoptosis is critical during development and mayaffect organ function. Apoptosis is accelerated in the presence of infection and inflammation in a variety of organsystems. The objective of this investigation was to determine if apoptosis was increased in the chorion laeve ofterm patients with and without histologic chorioamnionitis.

Methods: Records of placental pathology were reviewed with respect to the presence-absence of histologicchorioamnionitis. Sections from formalin-fixed, paraffin-embedded fetal membrane rolls were stained using theTUNEL method. The proportion of apoptotic nuclei was calculated in seven high-powered fields-section. Thosewith and without histologic chorioamnionitis were compared. Datawere analyzed using the Mann—Whitney U test,with significance defined as p < 0.05.

Results: There was no significant difference in demographic or clinical characteristics between the two groups.The chorion laeve from subjects with histologic chorioamnionitis had significantly more apoptotic nuclei whencompared to those without chorioamnionitis 11.2% vs. 5%, p = 0.02.

Conclusion: Apoptosis ismore prevalent in the chorion laeve of fetal membranes with histologic chorioamnionitis.This finding suggests that infection-inflammation may impact cell survivalwithin fetal membranes. The implicationsof these findings warrant further investigation.

Autor: A. P. Murtha, R. Auten, and W. N. P. Herbert

Fuente: https://www.hindawi.com/


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