Interleukin-23R rs7517847 T-G Polymorphism Contributes to the Risk of Crohn’s Disease in Caucasians: A Meta-AnalysisReportar como inadecuado




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Journal of Immunology Research - Volume 2015 2015, Article ID 279849, 5 pages -

Review Article

Liyang People’s Hospital, Liyang 213300, China

Translational Medicine Research Center of Jiangning Hospital and Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China

Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China

Received 27 June 2014; Revised 5 January 2015; Accepted 12 January 2015

Academic Editor: Guixiu Shi

Copyright © 2015 Li Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The association between Interleukin-23R gene polymorphism and Crohn’s disease CD in Caucasians is still controversial. Thus, a meta-analysis was performed to evaluate the correlation between this gene variant and CD risk. We retrieved the available data from EMBASE and PUBMED until May 1, 2014, and evaluated the effect of rs7517847 in Caucasians. The significant associations were confirmed between rs7517847 and CD risk in dominant models TT-TG versus GG: OR = 1.652, 95% CI 1.277, 2.137, allelic model T allele versus G allele: OR = 1.327, 95% CI 1.198, 1.469, homozygote comparison TT versus GG: OR = 1.890, 95% CI 1.465, 2.437, heterozygote comparison TG versus GG: OR = 1.509, 95% CI 1.161, 1.960, and recessive model TT versus TG-GG: OR = 1.409, 95% CI 1.279, 1.552. In conclusion, this meta-analysis demonstrates that rs7517847 is associated with the risk of CD in Caucasians. These findings show that IL-23R genes confer susceptibility to CD in the Caucasians.





Autor: Li Zhang, Yunjie Lu, Yuzheng Ge, Yun Shi, Xing Wu, Qinghua Xu, Xiaoping Li, Ling Lu, Feng Zhang, and Guozhong Yao

Fuente: https://www.hindawi.com/



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