Chlordecone exposure, length of gestation, and risk of preterm birth.Reportar como inadecuado

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* Corresponding author 1 Irset - Institut de recherche, santé, environnement et travail Rennes 2 Laboratory of Animal Ecology and Ecotoxicology

Abstract : Persistent organic pollutants have not been conclusively associated with length of gestation or with preterm birth. Chlordecone is an organochlorine pesticide that has been extensively used to control the banana root borer population in the French West Indies. Data from the Timoun Mother-Child Cohort Study conducted in Guadeloupe between 2004 and 2007 were used to examine the associations of chlordecone concentrations in maternal plasma with the length of gestation and the rate preterm birth in 818 pregnant women. Data were analyzed using multivariate linear regression for length of gestation and a Cox model for preterm birth. The median plasma chlordecone concentration was 0.39 µg-L interquartile range, 0.18-0.83. No correlation was observed with plasma concentrations of p,p-dichlorodiphenyl dichloroethene ρ = 0.017 or polychlorinated biphenyl 153 ρ = -0.016, the other main organochlorine compounds detected. A 1-log10 increase in chlordecone concentration was associated with a decreased length of gestation -0.27 weeks; 95% confidence interval: -0.50 -0.03 and an increased risk of preterm birth 60%; 95% confidence interval: 10, 130. These associations may result from the estrogen-like and progestin-like properties of chlordecone. These results are of public health relevance because of the prolonged persistence of chlordecone in the environment and the high background rate of preterm births in this population.

Keywords : preterm birth pesticides chlordecone French West Indies length of gestation persistent organic pollutants

Autor: Philippe Kadhel - Christine Monfort - Nathalie Costet - Florence Rouget - Jean-Pierre Thomé - Luc Multigner - Sylvaine Cordier -



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