Mitochondrial genes support a common origin of rodent malaria parasites and Plasmodium falciparums relatives infecting great apesReportar como inadecuado




Mitochondrial genes support a common origin of rodent malaria parasites and Plasmodium falciparums relatives infecting great apes - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 BONSAI - Bioinformatics and Sequence Analysis LIFL - Laboratoire d-Informatique Fondamentale de Lille, Inria Lille - Nord Europe 2 LIRMM - Laboratoire d-Informatique de Robotique et de Microélectronique de Montpellier 3 Goldman Group 4 MAB - Méthodes et Algorithmes pour la Bioinformatique LIRMM - Laboratoire d-Informatique de Robotique et de Microélectronique de Montpellier

Abstract : Background Plasmodium falciparum is responsible for the most acute form of human malaria. Most recent studies demonstrate that it belongs to a monophyletic lineage specialized in the infection of great ape hosts. Several other Plasmodium species cause human malaria. They all belong to another distinct lineage of parasites which infect a wider range of primate species. All known mammalian malaria parasites appear to be monophyletic. Their clade includes the two previous distinct lineages of parasites of primates and great apes, one lineage of rodent parasites, and presumably Hepatocystis species. Plasmodium falciparum and great ape parasites are commonly thought to be the sister-group of all other mammal-infecting malaria parasites. However, some studies supported contradictory origins and found parasites of great apes to be closer to those of rodents, or to those of other primates.ResultsTo distinguish between these mutually exclusive hypotheses on the origin of Plasmodium falciparum and its great ape infecting relatives, we performed a comprehensive phylogenetic analysis based on a data set of three mitochondrial genes from 33 to 84 malaria parasites. We showed that malarial mitochondrial genes have evolved slowly and are compositionally homogeneous. We estimated their phylogenetic relationships using Bayesian and maximum-likelihood methods. Inferred trees were checked for their robustness to the i site selection, ii assumptions of various probabilistic models, and iii taxon sampling. Our results robustly support a common ancestry of rodent parasites and Plasmodium falciparum-s relatives infecting great apes.ConclusionsOur results refute the most common view of the origin of great ape malaria parasites, and instead demonstrate the robustness of a less well-established phylogenetic hypothesis, under which Plasmodium falciparum and its relatives infecting great apes are closely related to rodent parasites. This study sheds light on the evolutionary history of Plasmodium falciparum, a major issue for human health.





Autor: Samuel Blanquart - Olivier Gascuel -

Fuente: https://hal.archives-ouvertes.fr/



DESCARGAR PDF




Documentos relacionados