Aluminum and silica in drinking water and the risk of Alzheimers disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort.Reportar como inadecuado




Aluminum and silica in drinking water and the risk of Alzheimers disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Epidémiologie et Biostatistique Bordeaux 2 ISPED - Institut de Santé Publique, d-Epidémiologie et de Développement

Abstract : The authors examined associations between exposure to aluminum or silica from drinking water and risk of cognitive decline, dementia, and Alzheimer-s disease among elderly subjects followed for 15 years 1988-2003. They actively searched for incident cases of dementia among persons aged 65 years or over living in 91 civil drinking-water areas in southern France. Two measures of exposure to aluminum were assessed: geographic exposure and individual exposure, taking into account daily consumption of tap water and bottled water. A total of 1,925 subjects who were free of dementia at baseline and had reliable water assessment data were analyzed. Using random-effects models, the authors found that cognitive decline with time was greater in subjects with a higher daily intake of aluminum from drinking water >or=0.1 mg-day, P=0.005 or higher geographic exposure to aluminum. Using a Cox model, a high daily intake of aluminum was significantly associated with increased risk of dementia. Conversely, an increase of 10 mg-day in silica intake was associated with a reduced risk of dementia adjusted relative risk =0.89, P=0.036. However, geographic exposure to aluminum or silica from tap water was not associated with dementia. High consumption of aluminum from drinking water may be a risk factor for Alzheimer-s disease.





Autor: Virginie Rondeau - Hélène Jacqmin-Gadda - Daniel Commenges - Catherine Helmer - Jean-François Dartigues -

Fuente: https://hal.archives-ouvertes.fr/



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