Fixation of Light Weight Polypropylene Mesh with n-Butyl-2-cyanocrylate in Pelvic Floor Surgery: Experimental Design Approach in Sheep for Effectiveness EvaluationReportar como inadecuado




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BioMed Research International - Volume 2015 2015, Article ID 737683, 9 pages -

Research Article

Department of Cell Biology, Physiology and Immunology, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, 08153 Barcelona, Spain

Integrated Services of Laboratory Animals, Universitat Autònoma de Barcelona, Bellaterra, 08153 Barcelona, Spain

B. Braun Surgical S.A., Rubi, 08191 Barcelona, Spain

Department of Animal Medicine and Surgery, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, 08153 Barcelona, Spain

Department of Animal Health and Anatomy, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, 08153 Barcelona, Spain

Received 29 March 2015; Accepted 15 June 2015

Academic Editor: Andrea Tinelli

Copyright © 2015 Sandra Barbosa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of this study was to find a proper experimental design and to evaluate n-butyl-2-cyanoacrylate Histoacryl as a fixation method for a light-weight and large pore PP mesh Synthetic PP Mesh-1 using the sheep as an animal model. Methods. Posterior vaginal implantation by means of episiotomy was used to implant 8 ewes which were evaluated macroscopically and histologically at 3 months and 6 months post-surgery. In previous pilot studies anterior vaginal implantation was evaluated, as well as different synthetic mesh materials, sizes and fixation methods to 3 during three weeks. In all cases a clinical evaluation of the animal was performed. Results. A reduction in the mesh size Synthetic PP Mesh-1 together with precise application of the surgical glue Histoacryl to fix the mesh yielded significantly better histocompatibility results compared to larger size or other fixation methods. Conclusion. The combination of Synthetic PP Mesh-1 with Histoacryl offered a high degree of graft integration without vaginal ulceration and a minimal foreign body reaction, being the sheep a proper animal model to test these types of medical devices.





Autor: Sandra Barbosa, Tania Nieves, Félix García, Eva Cepeda, Xavier Moll, Alberto Marco, Christine Weis, Pau Turon, and Patri

Fuente: https://www.hindawi.com/



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