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Journal of Diabetes Research - Volume 2015 2015, Article ID 737586, 11 pages -

Research Article

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA

Metabolism Research Center, IRCCS Policlinico San Donato, San Donato Milanese, Italy

Division of Metabolic and Cardiovascular Science, Metabolism, Nutrigenomics and CellularDifferentiation Unit, San Raffaele Scientific Institute, Milan, Italy

Received 21 May 2015; Accepted 14 July 2015

Academic Editor: Roberto Mallone

Copyright © 2015 Roberto Codella et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The nonobese diabetic NOD mouse represents a well-established experimental model analogous to human type 1 diabetes mellitus T1D as it is characterized by progressive autoimmune destruction of pancreatic β-cells. Experiments were designed to investigate the impact of moderate-intensity training on T1D immunomodulation and inflammation. Under a chronic exercise regime, NOD mice were trained on a treadmill for 12 weeks 12 m-min for 30 min, 5 d-wk while age-matched, control animals were left untrained. Prior to and upon completion of the training period, fed plasma glucose and immunological soluble factors were monitored. Both groups showed deteriorated glycemic profiles throughout the study although trained mice tended to be more compensated than controls after 10 weeks of training. An exercise-induced weight loss was detected in the trained mice with respect to the controls from week 6. After 12 weeks, IL-6 and MIP-1β were decreased in the trained animals compared to their baseline values and versus controls, although not significantly. Morphometric analysis of pancreata revealed the presence of larger infiltrates along with decreased α-cells areas in the control mice compared to trained mice. Exercise may exert positive immunomodulation of systemic functions with respect to both T1D and inflammation, but only in a stringent therapeutic window.

Autor: Roberto Codella, Giacomo Lanzoni, Alessia Zoso, Andrea Caumo, Anna Montesano, Ileana M. Terruzzi, Camillo Ricordi, Livio Lu



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