Streptozotocin-Induced Diabetes Decreases Mammary Gland Lipoprotein Lipase Activity and Messenger Ribonucleic Acid in Pregnant and Nonpregnant RatsReportar como inadecuado




Streptozotocin-Induced Diabetes Decreases Mammary Gland Lipoprotein Lipase Activity and Messenger Ribonucleic Acid in Pregnant and Nonpregnant Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

International Journal of Experimental Diabetes Research - Volume 3 2002, Issue 1, Pages 61-68



Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, Madrid, Spain

Facultad de Ciencias Experimentales y Técnicas, Universidad San Pablo-CEU, Boadilla del Monte Madrid E-28668, Spain

Received 4 October 2001; Accepted 28 October 2001

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes mellitus is associated with a reductionof lipoprotein lipase LPL activity in adiposetissue and development of hypertriglyceridemia.To determine how a condition ofsevere insulin deficiency affects mammarygland LPL activity and mRNA expression duringlate pregnancy, streptozotocin STZ treated40 mg-kg and non-treated control virginand 20 day pregnant rats were studied. In controlrats, both LPL activity and mRNA werehigher in pregnant than in virgin rats. Whencompared to control rats, STZ-treated rats,either pregnant or virgin, showed decreasedLPL activity and mRNA content. Furthermore,mammary gland LPL activity was linearly correlatedwith mRNA content, and either variablewas linearly correlated with plasma insulin levels. Thus, insulin deficiency impairs theexpression of LPL in mammary glands, revealingthe role of insulin as a modulator of theenzyme at the mRNA expression level.





Autor: Laura Blanco-Dolado, Antonia Martín-Hidalgo, and Emilio Herrera

Fuente: https://www.hindawi.com/



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