Planned Pregnancy in a Chronic Myeloid Leukemia Patient in Molecular RemissionReport as inadecuate

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Case Reports in HematologyVolume 2012 2012, Article ID 624590, 4 pages

Case Report

FUNDALEU, Centro de Internación e Investigación Clínica Angélica Ocampo, Pte José E. Uriburu 1520, C1114AANP Buenos Aires, Argentina

IFER, Instituto de Ginecología y Fertilidad, Buenos Aires, Argentina

Received 29 January 2012; Accepted 6 March 2012

Academic Editors: N. Hamerschlak, M.-C. Kyrtsonis, S. Storti, and P. Tsirigotis

Copyright © 2012 Carolina Pavlovsky et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Excellent response rates and a good quality of life have been observed since the introduction of tyrosine kinase inhibitors TKIs in chronic myeloid leukemia CML treatment. Consequently, some challenges began to appear in CML women in child-bearing age wishing to become pregnant. Currently, many women around the world are in stable major-complete molecular response MMR-CMR MMR: <0.1% BCR-ABL-ABL and CMR: undetectable BCR-ABL mRNA by RQ-PCR transcript levels on the international scale. The condition of stable MMR-CMR is linked to a long-term virtual absence of progression to the accelerated and blastic phase and to the possibility of stopping the TKI treatment with the maintenance of a condition of CMR in a proportion of cases. Imatinib teratogenic and prescribing information prohibits the use of it during pregnancy. We describe the case of a 36-year-old female patient with CML in chronic phase who stopped imatinib after 2 years in major molecular response MMR to plan a pregnancy. Molecular monitoring by RQ-PCR was performed quarterly. She achieved a safe pregnancy and delivery maintaining an optimal molecular response throughout the pregnancy. Isolated literature reports have been described, but no formal advice has been described at present time.

Author: Carolina Pavlovsky, Isabel Giere, and Germán Van Thillo



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