Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive DisorderReport as inadecuate




Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder - Download this document for free, or read online. Document in PDF available to download.

The Scientific World Journal - Volume 2014 2014, Article ID 624395, 7 pages -

Research Article

Department of Psychiatry, Çumra State Hospital, 42500 Konya, Turkey

Department of Psychiatry, School of Medicine, Bezmialem Vakif University, 34093 Istanbul, Turkey

Department of Biochemistry, School of Medicine, Atatürk University, 25240 Erzurum, Turkey

Department of Psychiatry, Konya Training and Research Hospital, 42090 Konya, Turkey

Department of Neurology, School of Medicine, Atatürk University, 25240 Erzurum, Turkey

Department of Psychiatry, School of Medicine, Medeniyet University, 34722 Istanbul, Turkey

Department of Psychiatry, School of Medicine, Atatürk University, 25240 Erzurum, Turkey

Received 12 August 2013; Accepted 27 October 2013; Published 16 January 2014

Academic Editors: V. Di Michele and S. Ueda

Copyright © 2014 Serpil Canpolat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the relationship of serum nitric oxide NO and asymmetrical dimethylarginine ADMA levels with cognitive functioning in patients with major depressive disorder MDD. 41 MDD patients Beck depression scale scores >16 and 44 controls were included in the study. Rey verbal learning and memory test, auditory consonant trigram test, digit span test, Wisconsin card sorting test, continuous performance task TOVA, and Stroop test scores were found to be impaired in patients with major depressive disorder when compared to healthy controls. There was no significant difference between patient and control groups in terms of serum NO and ADMA. Serum NO levels were correlated with TOVA test error scores and Stroop test time scores, whereas serum ADMA levels were negatively correlated with TOVA test error scores. Metabolic detriments especially in relation to NO metabolism in frontal cortex and hypothalamus, psychomotor retardation, or loss of motivation may explain these deficits.





Author: Serpil Canpolat, İsmet Kırpınar, Erdem Deveci, Hülya Aksoy, Zafer Bayraktutan, İbrahim Eren, Recep Demir, Salih Selek,

Source: https://www.hindawi.com/



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