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Mediators of Inflammation - Volume 2015 2015, Article ID 624287, 8 pages -

Review Article

Facultad de Medicina y Odontología, Universidad Católica de Valencia “San Vicente Mártir”, C-Quevedo 2, 46001 Valencia, Spain

Unidad Predepartamental de Medicina, Universitat Jaume I, 12071 Castellón de la Plana, Spain

Received 11 July 2014; Revised 18 September 2014; Accepted 18 November 2014

Academic Editor: Yuh-Lien Chen

Copyright © 2015 Jorge M. Barcia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes and alcohol misuse are two of the major challenges in health systems worldwide. These two diseases finally affect several organs and systems including the central nervous system. Hippocampus is one of the most relevant structures due to neurogenesis and memory-related processing among other functions. The present review focuses on the common profile of diabetes and ethanol exposure in terms of oxidative stress and proinflammatory and prosurvival recruiting transcription factors affecting hippocampal neurogenesis. Some aspects around antioxidant strategies are also included. As a global conclusion, the present review points out some common hits on both diseases giving support to the relations between alcohol intake and diabetes.





Author: Jorge M. Barcia, Miguel Flores-Bellver, Maria Muriach, Javier Sancho-Pelluz, Daniel Lopez-Malo, Alba C. Urdaneta, Natalia Ma

Source: https://www.hindawi.com/



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