Clinical Findings and Genetic Expression Profiling of Three Pigmented Lesions of the Optic NerveReport as inadecuate

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Case Reports in Ophthalmological Medicine - Volume 2015 2015, Article ID 590659, 7 pages -

Case ReportMurray Ocular Oncology and Retina, 6705 Red Road, Suite 412, Miami, FL 33143, USA

Received 9 January 2015; Revised 24 March 2015; Accepted 25 March 2015

Academic Editor: Takaaki Hayashi

Copyright © 2015 Manuel A. de Alba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Optic disk melanocytoma is a primary tumor of the optic disk that represents a clinical diagnostic challenge due to its similarities with melanoma. Purpose. The authors present three cases in which genetic expression profiling was used to identify tumor prognosis of optic disk melanocytoma. Case Series. In two cases fine-needle aspiration biopsy was performed to obtain tissue through a transvitreal route into the apex of the tumor while the patient underwent pars plana vitrectomy, laser ablation, phacoemulsification with posterior chamber intraocular lens implantation, and intravitreal triamcinolone acetonide. In the other case the tissue was obtained after definite enucleation. Conclusion. Genetic expression profiling is a useful diagnostic tool for classification and can provide vital information to the ocular oncologist regarding prognosis.

Author: Manuel A. de Alba, Victor M. Villegas, Aaron S. Gold, Andrea Wildner, Fiona J. Ehlies, Azeema Latiff, and Timothy G. Murray



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