Efficient Catalyst One-Pot Synthesis of 7-Aryl-10,10-dimethyl-10,11-dihydrochromeno4,3-bchromene-6,87H,9H-dione Derivatives Complemented by Antibacterial ActivityReport as inadecuate




Efficient Catalyst One-Pot Synthesis of 7-Aryl-10,10-dimethyl-10,11-dihydrochromeno4,3-bchromene-6,87H,9H-dione Derivatives Complemented by Antibacterial Activity - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2016 2016, Article ID 5891703, 7 pages -

Research Article

Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia UKM, 43000 Bangi, Selangor, Malaysia

Environmental Research Center, University of Technology UOT, Baghdad 10001, Iraq

Fuel Cell Institute, Universiti Kebangsaan Malaysia UKM, 43000 Bangi, Selangor, Malaysia

Received 4 May 2016; Accepted 4 July 2016

Academic Editor: Lucia Lopalco

Copyright © 2016 Yasameen K. Al-Majedy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-aryl-10,10-dimethyl-10,11-dihydrochromeno4,3-bchromene-6,87H,9H-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide TBAB, diammonium hydrogen phosphate DAHP, or ferric chloride FeCl3, respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity.





Author: Yasameen K. Al-Majedy, Ahmed A. Al-Amiery, Abdul Amir H. Kadhum, and Abu Bakar Mohamad

Source: https://www.hindawi.com/



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