Physalis alkekengi Carotenoidic Extract Inhibitor of Soybean Lipoxygenase-1 ActivityReport as inadecuate




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BioMed Research International - Volume 2014 2014, Article ID 589168, 7 pages -

Research Article

Laboratory of Animal Biology, National Research Development Institute for Animal Biology and Nutrition Baloteşti IBNA, Calea Bucureşti Nr. 1, Baloteşti, 077015 Ilfov, Romania

University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, 3-5 Manastur Street, 400372 Cluj-Napoca, Romania

Department of Functional Genomics and Experimental Pathology, Chiricuta Cancer Institute, 400015 Cluj-Napoca, Romania

Received 30 April 2013; Revised 14 October 2013; Accepted 18 October 2013; Published 9 January 2014

Academic Editor: José Domingos Fontana

Copyright © 2014 Veronica Sanda Chedea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to evaluate the effect of the carotenoidic saponified extract of Physalis alkekengi sepals PA towards the lipoxygenase LOX oxidation of linoleic acid. Lipoxygenase activity in the presence of carotenoids, standard and from extract, was followed by its kinetic behaviour determining the changes in absorption at 234 nm. The standard carotenoids used were -carotene -car, lutein Lut, and zeaxanthin Zea. The calculated enzymatic specific activity ESA after 600 s of reaction proves that PA carotenoidic extract has inhibitory effect on LOX oxidation of linoleic acid. A longer polyenic chain of carotenoid structure gives a higher ESA during the first reaction seconds. This situation is not available after 600 s of reaction and may be due to a destruction of this structure by cooxidation of carotenoids, besides the classical LOX reaction. The PA carotenoidic extract inhibiting the LOX-1 reaction can be considered a source of lipoxygenase inhibitors.





Author: Veronica Sanda Chedea, Adela Pintea, Andrea Bunea, Cornelia Braicu, Andreea Stanila, and Carmen Socaciu

Source: https://www.hindawi.com/



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