Quantification in time-domain diffuse optical tomography using Mellin-Laplace transformsReport as inadecuate




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1 CEA-LETI - Laboratoire d-Electronique et des Technologies de l-Information 2 Dipartimento di Fisica 3 MOTIV LIPhy - Laboratoire Interdisciplinaire de Physique Saint Martin d’Hères

Abstract : Simulations and phantom measurements are used to evaluate the ability of time-domain diffuse optical tomography using Mellin-Laplace transforms to quantify the absorption perturbation of centimetric objects immersed at depth 1-2 cm in turbid media. We find that the estimated absorption coefficient varies almost linearly with the absorption change in the range of 0-0.15 cm−1 but is underestimated by a factor that depends on the inclusion depth ~2, 3 and 6 for depths of 1.0, 1.5 and 2.0 cm respectively. For larger absorption changes, the variation is sublinear with ~20% decrease for δμa = 0.37 cm−1. By contrast, constraining the absorption change to the actual volume of the inclusion may considerably improve the accuracy and linearity of the reconstructed absorption.

Keywords : Time-resolved imaging Tomography Image reconstruction techniques Imaging through turbid media Photon counting Photodetectors





Author: Judy Zouaoui - Laura Di Sieno - Lionel Hervé - Antonio Pifferi - Andrea Farina - Alberto Dalla Mora - Jacques Derouard - Jean-Ma

Source: https://hal.archives-ouvertes.fr/



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