Development and In Vitro Characterization of Hyaluronic Acid-Based Coatings for Implant-Associated Local Drug Delivery SystemsReport as inadecuate

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Journal of ChemistryVolume 2013 2013, Article ID 587875, 11 pages

Research ArticleInstitute for Biomedical Engineering, University of Rostock, Friedrich-Barnewitz-Straße 4, 18119 Rostock, Germany

Received 18 January 2013; Revised 13 March 2013; Accepted 20 March 2013

Academic Editor: Zexuan Dong

Copyright © 2013 Svea Petersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The development of drug-eluting coatings based on hyaluronic acid HA is especially promising for implant-associated local drug delivery LDD systems, whose implantation provokes high insertion forces, as, for instance, cochlear implants or drug-coated balloons DCB. The lubricious character of HA can then reduce the coefficient of friction and serve as drug reservoir simultaneously. In this context, we investigated several plasma- and wet-chemical methods for the deposition of HA-based coatings with LDD function on polyamide 12 as a model implant surface, conventionally used for DCB. In contrast to aminosilane, epoxy silane surface layers allowed the covalent attachment of a smooth and uniform HA base layer, which provided good adherence of further HA layers deposited by manual dip coating at a subsequent processing stage. The applied HA-crosslinking procedure during dip coating influences the transfer and release of paclitaxel, which could be reproducibly incorporated via infiltration. While crosslinking with N-3-dimethylaminopropyl-N′-ethylcarbodiimide hydrochloride provided HA coatings on DCB, which allowed for an efficient paclitaxel transfer upon expansion in a vessel model, crosslinking with glutardialdehyde resulted in a slower drug release being more appropriate for implants with longer residence time in the body. The developed HA coating is hence well suited for spontaneous and sustained LDD.

Author: Svea Petersen, Sebastian Kaule, Michael Teske, Ingo Minrath, Klaus-Peter Schmitz, and Katrin Sternberg



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