UVA-UVB Photoprotective Activity of Topical Formulations Containing Morinda citrifolia ExtractReport as inadecuate

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BioMed Research International - Volume 2014 2014, Article ID 587819, 10 pages -

Research Article

Departamento de Fisiologia, Universidade Federal de Sergipe UFS, São Cristóvão, SE, Brazil

Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil

Instituto de Tecnologia e Pesquisa ITP, Aracaju, SE, Brazil

Faculdade de Ciências Farmacêuticas de Ribeirão Preto FCFRP, Ribeirão Preto, SP, Brazil

Received 15 April 2014; Accepted 19 June 2014; Published 15 July 2014

Academic Editor: Wan-Liang Lu

Copyright © 2014 Mairim Russo Serafini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Exposure to solar radiation, particularly its ultraviolet UV component, has a variety of harmful effects on human health. Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. The beneficial photoprotective effects of topical formulations with the extract, Morinda citrifolia, have not been investigated. This present study aims to investigate the potential benefits of M. citrifolia topical application on the dorsal skin of mice, exposed to UVA-UVB light. Using 7 days of treatment, before baseline values and 20 h after UV exposure, the thickness, skin barrier damage TEWL, erythema, and histological alterations were evaluated. The results showed that the formulations containing the extract protected the skin against UV-induced damage.

Author: Mairim Russo Serafini, Cassia Britto Detoni, Paula dos Passos Menezes, Rose Nely Pereira Filho, Vanessa Silveira Fortes, Mari

Source: https://www.hindawi.com/


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