Fetal Brain Transplantation in Kainic Acid Lesioned Caudate Nucleus of Adult RatsReportar como inadecuado




Fetal Brain Transplantation in Kainic Acid Lesioned Caudate Nucleus of Adult Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Neural Transplantation and Plasticity - Volume 3 1992, Issue 2-3, Pages 125-133



Department of Physiology and National Facility for Neural Transplant, All India Institute of Medical Sciences, New Delhi 110029, India

Department of Neurosurgery and National Facility for Neural Transplant, All India Institute of Medical Sciences, New Delhi 110029, India

Department of Anatomy and National Facility for Neural Transplant, All India Institute of Medical Sciences, New Delhi 110029, India



Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study confirmed that bilateral kainie acid KA injection at the caudate produces aphagia and adipsia in rats. The reduction in food and water intake was fatal after a higher dosage of the drug. To test the effect of transplantation on. the mortality, rate, KA was first injected in the left caudate, in one set of rats. After a gap of three days, fetal striatal tissue was unilaterally transplanted at this lesioned site, along with a second injection of KA in the right caudate. Successful transplantation, as ascertained morphologically, did not significantly alter the mortality rate. The morphometric study revealed that the neurons of the transplant were larger in size, and their numerical density lower than those of the caudate of normal rats. Only very few neurons of the transplant developed functional connectivity with the host, as demonstrated by electrophysiological studies.





Autor: P. N. Tandon, V. Mohan Kumar, Suneeta Verma, Gomathi Gopinath, and Ashok Kumar Shetty

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados