Analgesic, Anti-Inflammatory, and GC-MS Studies on Castanospermum australe A. Cunn. & C. Fraser ex Hook.Reportar como inadecuado




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The Scientific World Journal - Volume 2014 2014, Article ID 587807, 9 pages -

Research ArticleBioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore,Tamil Nadu 641 046, India

Received 31 August 2013; Accepted 19 December 2013; Published 2 February 2014

Academic Editors: E. Izbicka and S. Wu

Copyright © 2014 Thankarajan Sajeesh and Thangaraj Parimelazhagan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was aimed to evaluate the analgesic and anti-inflammatory properties of Castanospermum australe and to profile phytochemicals by GC-MS. The ethanolic extracts were prepared by successive solvent extraction using Soxhlet apparatus. The analgesic activity was analyzed by hot plate method and acetic acid-induced writhing test whereas anti-inflammatory study was done by carrageenan induced paw oedema model. The acute toxicity study revealed that ethanol extracts of leaf and bark of C. australe were safe even at a higher dose of 2000 mg-kg whereas ethanol extract of seed was toxic at the same dose. In both hot plate method 5.85 s and acetic acid-induced writhing test 57%, the leaf ethanol extract exhibited significant analgesic activity at a dose of 400 mg-kg. The anti-inflammatory activity of leaf extract was exhibited by the reduction in paw linear diameter by 64.76% at 400 mg-kg in carrageenan induced paw oedema. The GC-MS analysis of the ethanol extract of leaf revealed sixteen major compounds of which 1,7-dimethyl-4,10-dioxa-1,7-diazacyclododecane, +-N-methylephedrine, and permethylspermine were found to be pharmaceutically and the most important. These findings justify that C. australe can be a valuable natural analgesic and anti-inflammatory source which seemed to provide potential phytotherapeutics against various ailments.





Autor: Thankarajan Sajeesh and Thangaraj Parimelazhagan

Fuente: https://www.hindawi.com/



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