Time-Intensity Curve Parameters in Rectal Cancer Measured Using Endorectal Ultrasonography with Sterile Coupling Gels Filling the Rectum: Correlations with Tumor Angiogenesis and Clinicopathological FeaturesReportar como inadecuado




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BioMed Research InternationalVolume 2014 2014, Article ID 587806, 7 pages

Clinical Study

Department of Diagnostic Imaging, Cancer Hospital & Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China

Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong

Department of Pathology, Cancer Hospital & Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China

Department of Diagnostic Ultrasound, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China

Received 25 January 2014; Accepted 20 April 2014; Published 13 May 2014

Academic Editor: Zhiyi Chen

Copyright © 2014 Yong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The primary aim of this study was to investigate the relationship between contrast-enhanced ultrasonography CEUS imaging parameters and clinicopathological features of rectal carcinoma and assess their potential as new radiological prognostic predictors. A total of 66 rectal carcinoma patients were analyzed with the time-intensity curve of CEUS. The parameter arrival time AT, time to peak enhancement TTP, wash-in time WIT, enhanced intensity EI, and ascending slope AS were measured. Microvessel density MVD was evaluated by immunohistochemical staining of surgical specimens. All findings were analysed prospectively and correlated with tumor staging, histological grading, and MVD. The mean values of AT, TTP, WIT, EI, and AS value of the rectal carcinoma were  dB, and , respectively. A positive linear correlation was found between the EI and MVD in rectal carcinoma , and there was a significant difference for EI among histological grading . EI decreased as T stage increased with a trend of association noted . EI of contrast enhanced endorectal ultrasonography provides noninvasive biomarker of tumor angiogenesis in rectal cancer. CEUS data have the potential to predict patient prognosis.





Autor: Yong Wang, Lin Li, Yi-Xiang J. Wang, Ning-Yi Cui, Shuang-Mei Zou, Chun-Wu Zhou, and Yu-Xin Jiang

Fuente: https://www.hindawi.com/



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