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International Scholarly Research NoticesVolume 2014 2014, Article ID 243080, 16 pages

Review ArticleDepartment of Oncourology, N.N. Petrov Research Institute of Oncology, 68 Leningradskaya Street, Pesochny, Saint Petersburg 197758, Russia

Received 5 March 2014; Accepted 19 May 2014; Published 15 July 2014

Academic Editor: Athanasios Papatsoris

Copyright © 2014 Sergey Reva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recent therapeutic advances for managing low-risk prostate cancer include the active surveillance and focal treatment. However, locating a tumor and detecting its volume by adequate sampling is still problematic. Development of predictive biomarkers guiding individual therapeutic choices remains an ongoing challenge. At the same time, prostate cancer magnetic resonance imaging is gaining increasing importance for prostate diagnostics. The high morphological resolution of T2-weighted imaging and functional MRI methods may increase the specificity and sensitivity of diagnostics. Also, recent studies founded an ability of novel biomarkers to identify clinically insignificant prostate cancer, risk of progression, and association with poor differentiation and, therefore, with clinical significance. Probably, the above mentioned methods would improve tumor characterization in terms of its volume, aggressiveness, and focality. In this review, we attempted to evaluate the applications of novel imaging techniques and biomarkers in assessing the significance of the prostate cancer.

Autor: Sergey Reva, Alexander Nosov, Roman Novikov, and Sergey Petrov



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