Spectrophotometric Method for Determination of Five 1,4-Dihydropyridine Drugs Using N-Bromosuccinimide and Indigo Carmine DyeReportar como inadecuado




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International Journal of SpectroscopyVolume 2013 2013, Article ID 243059, 7 pages

Research Article

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Received 15 March 2013; Revised 10 July 2013; Accepted 17 July 2013

Academic Editor: Hakan Arslan

Copyright © 2013 Mohamed A. El Hamd et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Indirect spectrophotometric method is described for quantification of five of 1,4-dihydropyridine 1,4-DHP drugs using N-bromosuccinimide NBS with the aid of indigo carmine INC dye. The method is based on addition of known excess of NBS to an acidified solution of 1,4-DHP drugs and determining the residual of NBS through its ability to bleach the colour of the used dye; the amount of NBS that reacted corresponded to the amount of drugs. Beer’s law is obeyed in the concentration range 1.25–13.00 μg-mL. Good correlation coefficients 0.998-0.999 were found between the absorbance values and the corresponding concentrations. Limits of detections ranged from 0.141 to 0.500 μg-mL. The proposed method was successfully applied to the analysis of dosage forms; percent of recoveries ranged from 97.31 to 99.46% without interference from any common excipients. The statistical comparison by Student’s t-test and variance ratio F-test showed no significant difference between the proposed and official or reported methods.





Autor: Mohamed A. El Hamd, Sayed M. Derayea, Osama H. Abdelmageed, and Hassan F. Askal

Fuente: https://www.hindawi.com/



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