Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine Active Component Isolated from Rhizoma Chuanxiong: Roles and MechanismsReportar como inadecuado




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BioMed Research International - Volume 2016 2016, Article ID 2430329, 9 pages -

Review Article

Centre of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China

China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China

Received 18 January 2016; Revised 7 April 2016; Accepted 27 April 2016

Academic Editor: Guoyan Yang

Copyright © 2016 Ming Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tetramethylpyrazine TMP, a pharmacologically active component isolated from the rhizome of the Chinese herb Rhizoma Chuanxiong Chuanxiong, has been clinically used in China and Southeast Asian countries for the prevention and treatment of cardiovascular diseases CVDs for about fifty years. The pharmacological effects of TMP on the cardiovascular system have attracted great interest. Emerging experimental studies and clinical trials have demonstrated that TMP prevents atherosclerosis as well as ischemia-reperfusion injury. The cardioprotective effects of TMP are mainly related to its antioxidant, anti-inflammatory, or calcium-homeostasis effects. This review focuses on the roles and mechanisms of action of TMP in the cardiovascular system and provides a novel perspective on TMP’s clinical use.





Autor: Ming Guo, Yue Liu, and Dazhuo Shi

Fuente: https://www.hindawi.com/



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