Pressure Drop in Tortuosity-Kinking of the Internal Carotid Artery: Simulation and Clinical InvestigationReportar como inadecuado




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BioMed Research International - Volume 2016 2016, Article ID 2428970, 8 pages -

Research Article

Department of Neurosurgery, Beijing Hospital, Beijing 100730, China

Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China

Received 18 November 2015; Revised 24 February 2016; Accepted 15 March 2016

Academic Editor: Venkatesh Mani

Copyright © 2016 Lijun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Whether carotid tortuosity-kinking of the internal carotid artery leads to cerebral ischemia remains unclear. There is very little research about the hemodynamic variation induced by carotid tortuosity-kinking in the literature. The objective of this study was to research the blood pressure changes induced by carotid tortuosity-kinking. Methods. We first created a geometric model of carotid tortuosity-kinking. Based on hemodynamic boundary conditions, the hemodynamics of carotid tortuosity and kinking were studied via a finite element simulation. Then, an in vitro system was built to validate the numerical simulation results. The mean arterial pressure changes before and after carotid kinking were measured using pressure sensors in 12 patients with carotid kinking. Results. Numerical simulation revealed that the pressure drops increased with increases in the kinking angles. Clinical tests and in vitro experiments confirmed the numerical simulation results. Conclusions. Carotid kinking leads to blood pressure reduction. In certain conditions, kinking may affect the cerebral blood supply and be associated with cerebral ischemia.





Autor: Lijun Wang, Feng Zhao, Daming Wang, Shen Hu, Jiachun Liu, Zhilun Zhou, Jun Lu, Peng Qi, and Shiying Song

Fuente: https://www.hindawi.com/



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