The concerted modulation of proliferation and migration contributes to the specification of the cytoarchitecture and dimensions of cortical areasReportar como inadecuado




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* Corresponding author 1 Cerveau et vision 2 Service Gynécologie Obstétrique 3 Department of Anatomy and Physiology, School of life sciences

Abstract : Regionalization of cell-cycle kinetics of cortical precursors has been described in non-human primates and rodents indicating a fate map of areal distinct proliferative programs in the germinal zones of the neocortex. It remains to be understood how proliferative gradients during corticogenesis are transcribed into a stepwise function to form adult areal borders. Here we have used the monkey areas17 and 18, which show striking cytoarchitectonic differences as a model system for studying how developmental events establish areal boundaries in the adult. We present data indicating that the events that are involved in the formation of a sharp border separating two areas involve an orchestration of diverse phenomena including differential rates of proliferation, migration and tangential expansion.

keyword : cortical plate primate neocortex subventricular zone cortical plate.





Autor: Agnès Lukaszewicz - Véronique Cortay - Pascale Giroud - Michel Berland - Iain Smart - Henry Kennedy - Colette Dehay -

Fuente: https://hal.archives-ouvertes.fr/



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