Tuning Eye-Gaze Perception by Transitory STS InhibitionReportar como inadecuado

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* Corresponding author 1 IHU - Imagine - Institut des maladies génétiques 2 Service de pédiatrie générale 3 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute 4 UP11 UFR Médecine - Université Paris-Sud 11 - Faculté de médecine 5 CHU Pitié-Salpêtrière APHP

Abstract : Processing eye-gaze information is a key step to human social interaction. Neuroimaging studies have shown that superior temporal sulcus STS is highly implicated in eye-gaze perception. In autism, a lack of preference for the eyes, as well as anatomo-functional abnormalities within the STS, has been described. To date, there are no experimental data in humans showing whether it is possible to interfere with eye-gaze processing by modulating STS neural activity. Here, we measured eye-gaze perception before and after inhibitory transcranial magnetic stimulation TMS applied over the posterior STS pSTS in young healthy volunteers. Eye-gaze processing, namely overt orienting toward the eyes, was measured using eye tracking during passive visualization of social movies. Inhibition of the right pSTS led participants to look less to the eyes of characters during visualization of social movies. Such effect was specific for the eyes and was not observed after inhibition of the left pSTS nor after placebo TMS. These results indicate for the first time that interfering with the right pSTS neural activity transitorily disrupts the behavior of orienting toward the eyes and thus indirectly gaze perception, a fundamental process for human social cognition. These results could open up new perspectives in therapeutic interventions in autism.

Keywords : STS social cognition eye-gaze perception TMS

Autor: Ana Saitovitch - Traian Popa - Hervé Lemaitre - Elza Rechtman - Jean-Charles Lamy - David Grévent - Raphael Calmon - Sabine Meu

Fuente: https://hal.archives-ouvertes.fr/


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