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The Scientific World Journal - Volume 2015 2015, Article ID 956235, 7 pages -

Research Article

Department of Pharmacology, Faculty of Medical Sciences, University of Campinas UNICAMP, 13083-970 Campinas, SP, Brazil

Department of Structural and Functional Biology, Institute of Biology, University of Campinas UNICAMP, 13083-970 Campinas, SP, Brazil

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas UNICAMP, 13083-970 Campinas, SP, Brazil

Department of Biological Sciences, Federal University of Goiás UFG, Regional Catalão, 75704-020 Catalão, GO, Brazil

Received 28 July 2014; Revised 15 October 2014; Accepted 22 October 2014

Academic Editor: Inaya Hajj Hussein

Copyright © 2015 Luis Paulo Manzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Royal Jelly RJ is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory. We have investigated the role of RJ in the development of TNBS colitis in mice. Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. Intestine samples of the animals orally treated with RJ 100, 150, and 200 mg-kg were collected for antioxidant assays GSH and GSH-Px, proinflammatory protein quantification COX-2 and NF-κB, and histological analyses. RJ 100 mg-kg maintained GSH levels and increased the activity of GSH-Px, downregulated key inflammatory mediators COX-2 and NF-κB, and decreased the lesions caused by TNBS as shown by the histological analyses. In conclusion, RJ showed anti-inflammatory and antioxidant properties in experimental colitis, resulting in the amelioration of the macroscopic and histological analyses. These results corroborate with the RJ supplementation in diets.





Autor: Luis Paulo Manzo, Felipe Meira de-Faria, Ricardo José Dunder, Eduardo Augusto Rabelo-Socca, Silvio Roberto Consonni, Ana Cri

Fuente: https://www.hindawi.com/



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