Multiple Congenital Granular Cell Epulis: Case Report and Immunohistochemical Profile with Emphasis on VascularizationReportar como inadecuado

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Case Reports in Dentistry - Volume 2015 2015, Article ID 878192, 5 pages -

Case ReportDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, 13045-755 Campinas, SP, Brazil

Received 10 December 2014; Accepted 24 January 2015

Academic Editor: Ronald S. Brown

Copyright © 2015 Patricia Roccon Bianchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Congenital granular cell epulis is a rare benign soft tissue lesion arising from the alveolar ridge in neonates. A rare case of multiple congenital granular cell epulis is reported, alongside a description of its vascular immunohistochemical profile. A female newborn presented with two exophytic pedunculated red nodules located on the alveolar ridge between the future eruption sites of the incisors and canines of the mandible and maxilla. A conservative surgical excision was performed on the second day of life. Histology revealed proliferation of round granular cells containing an abundant eosinophilic cytoplasm with basophilic nuclei, ranging from round to oval in shape. Numerous blood vessels were also seen. Immunohistochemical analysis of the granular cells revealed positivity for CD68, D2-40, Ki67, VEGF, and FGF and negativity for S100, CD34, and CD105. Immunostaining for CD34, CD105, and D2-40 confirmed the presence of a large number of blood and lymphatic vessels. Although rare, an understanding of this lesion is paramount for correct diagnosis and appropriate treatment. In the present report, the immunohistochemical profile confirmed increased vascularization, proving that these lesions are composed of not only new and preexisting blood vessels, but also lymphatic vessels.

Autor: Patricia Roccon Bianchi, Vera Cavalcanti de Araujo, José Wagner Banterli Ribeiro, Fabricio Passador-Santos, Ney Soares de Ara



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