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1 M3DISIM - Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine LMS - Laboratoire de mécanique des solides, Inria Saclay - Ile de France 2 LMS - Laboratoire de mécanique des solides

Abstract : Mechanically induced folding of passive cross-linkers is a fundamental biological phenomenon. A typical example is a conformational change in myosin II responsible for the power-stroke in skeletal muscles. In this paper we present an athermal perspective on such folding by analyzing the simplest purely mechanical prototype: a parallel bundle of bi-stable units attached to a common backbone. We show that in this analytically transparent model, characterized by a rugged energy landscape, the ground states are always highly coherent, single-phase configurations. We argue that such cooperative behavior, ensuring collective conformational change, is due to the dominance of long- range interactions making the system non-additive. The detailed predictions of our model are in agreement with experimentally observed non-equivalence of fast force recovery in skeletal muscles loaded in soft and hard devices. Some features displayed by the model are also recognizable in the behavior of other biological systems with passive multi-stability and long-range interactions including detaching adhesive binders and pulled RNA-DNA hairpins.

Keywords : Huxley-Simmons model long-range interactions power-stroke metamaterials protein folding hairpins

Autor: Matthieu Caruel - Jean-Marc Allain - Lev Truskinovsky -



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