Poor glycemic control in type 2 diabetes enhances functional and compositional alterations of small, dense HDL3cReportar como inadecuado

Poor glycemic control in type 2 diabetes enhances functional and compositional alterations of small, dense HDL3c - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition 2 University of Buenos Aires 3 Ramón Carrillo Centre 4 Italian Hospital of Buenos Aires 5 Russian Academy of Medical Sciences 6 Institute for Atherosclerosis Research Moscou

Abstract : High-density lipoprotein HDL possesses multiple biological activities; small, dense HDL3c particles displaying distinct lipidomic composition exert potent antiatherogenic activities which can be compromised in dyslipidemic, hyperglycemic insulin-resistant states. However, it remains indeterminate i whether such functional HDL deficiency is related to altered HDL composition, and ii whether it originates from atherogenic dyslipidemia, dysglycemia, or both.In the present work we analyzed compositional characteristics of HDL subpopulations and functional activity of small, dense HDL3c particles in treatment-naïve patients with well-controlled n = 10 and poorly-controlled n = 8 type 2 diabetes T2D and in normolipidemic age- and sex-matched controls n = 11.Our data reveal that patients with both well- and poorly-controlled T2D displayed dyslipidemia and low-grade inflammation associated with altered HDL composition. Such compositional alterations in small, dense HDL subfractions were specifically correlated with plasma HbA1c levels. Further analysis using a lipidomic approach revealed that small, dense HDL3c particles from T2D patients with poor glycemic control displayed additional modifications of their chemical composition. In parallel, antioxidative activity of HDL3c towards oxidation of low-density lipoprotein was diminished.These findings indicate that defective functionality of small, dense HDL particles in patients with T2D is not only affected by the presence of atherogenic dyslipidemia, but also by the level of glycemic control, reflecting compositional alterations of HDL

Keywords : Type 2 diabetes Functionality Lipidomics HDL Antioxidative activity

Autor: Leonardo Gomez Rosso - Marie Lhomme - Tomas Meroño - Ana Dellepiane - Patricia Sorroche - Lyamine Hedjazi - Emile Zakiev - Vasil

Fuente: https://hal.archives-ouvertes.fr/


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