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BioMed Research InternationalVolume 2014 2014, Article ID 435197, 19 pages

Review ArticleSignal Transduction in Cancer and Stem Cells Laboratory, Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology CSIR-IICB, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India

Received 27 March 2014; Revised 26 May 2014; Accepted 28 May 2014; Published 9 July 2014

Academic Editor: Dong Wang

Copyright © 2014 Seemana Bhattacharya and Mrinal Kanti Ghosh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The process of cell death has important physiological implications. At the organism level it is mostly involved in maintenance of tissue homeostasis. At the cellular level, the strategies of cell death may be categorized as either suicide or sabotage. The mere fact that many of these processes are programmed and that these are often deregulated in pathological conditions is seed to thought. The various players that are involved in these pathways are highly regulated. One of the modes of regulation is via post-translational modifications such as ubiquitination and deubiquitination. In this review, we have first dealt with the different modes and pathways involved in cell death and then we have focused on the regulation of several proteins in these signaling cascades by the different deubiquitinating enzymes, in the perspective of cancer. The study of deubiquitinases is currently in a rather nascent stage with limited knowledge both in vitro and in vivo, but the emerging roles of the deubiquitinases in various processes and their specificity have implicated them as potential targets from the therapeutic point of view. This review throws light on another aspect of cancer therapeutics by targeting the deubiquitinating enzymes.

Autor: Seemana Bhattacharya and Mrinal Kanti Ghosh

Fuente: https://www.hindawi.com/


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