Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in MiceReportar como inadecuado




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Journal of Immunology Research - Volume 2015 2015, Article ID 435140, 9 pages -

Research Article

Department of Ophthalmology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA

Received 6 April 2015; Accepted 23 June 2015

Academic Editor: Kurt Blaser

Copyright © 2015 Xiao-Tang Yin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Herpes simplex virus-1 HSV-1 infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis HSK. Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a latent viral infection of the trigeminal ganglia. One of the key factors that limit inflammation of the cornea is the expression of Fas ligand FasL. We demonstrate that infection of the cornea with HSV-1 results in increased functional expression of FasL and that mice expressing mutations in Fas lpr and FasL gld display increased recurrent HSK following reactivation compared to wild-type mice. Furthermore, both gld and lpr mice took longer to clear their corneas of infectious virus and the reactivation rate for these strains was significantly greater than that seen with wild-type mice. Collectively, these findings indicate that the interaction of Fas with FasL in the cornea restricts the development of recurrent HSK.





Autor: Xiao-Tang Yin, Tammie L. Keadle, Jessicah Hard, John Herndon, Chloe A. Potter, Chelsea R. Del Rosso, Thomas A. Ferguson, an

Fuente: https://www.hindawi.com/



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