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Advances in Pharmacological SciencesVolume 2011 2011, Article ID 435132, 7 pages

Review Article

Department of Physiology, Georgia Health Sciences University, 1120 Fifteenth Street, CA-3135, Augusta, GA 30912-3000, USA

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049-900 Sao Paulo, SP, Brazil

Received 9 August 2011; Accepted 21 September 2011

Academic Editor: Masahiro Oike

Copyright © 2011 Takayuki Matsumoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate Up4A has been identified as a novel and potent endothelium-derived contracting factor EDCF. Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

Autor: Takayuki Matsumoto, Rita C. Tostes, and R. Clinton Webb



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