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Stem Cells InternationalVolume 2013 2013, Article ID 435093, 7 pages

Review Article

Department of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center and Chao Family Comprehensive Cancer Center, University of California, Irvine, 845 Health Sciences Road, Irvine, CA 92697, USA

Department of Biomedical Engineering and Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 845 Health Sciences Road, Irvine, CA 92697, USA

Department of Developmental & Cell Biology, University of California, Irvine, 4236 McGaugh Hall, Irvine, CA 92697, USA

Received 30 April 2013; Accepted 13 July 2013

Academic Editor: Donald G. Phinney

Copyright © 2013 Linan Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Systemically infused mesenchymal stem cells MSCs are emerging therapeutics for treating stroke, acute injuries, and inflammatory diseases of the central nervous system CNS, as well as brain tumors due to their regenerative capacity and ability to secrete trophic, immune modulatory, or other engineered therapeutic factors. It is hypothesized that transplanted MSCs home to and engraft at ischemic and injured sites in the brain in order to exert their therapeutic effects. However, whether MSCs possess the ability to migrate across the blood-brain barrier BBB that separates the blood from the brain remains unresolved. This review analyzes recent advances in this area in an attempt to elucidate whether systemically infused MSCs are able to actively transmigrate across the CNS endothelium, particularly under conditions of injury or stroke. Understanding the fate of transplanted MSCs and their CNS trafficking mechanisms will facilitate the development of more effective stem-cell-based therapeutics and drug delivery systems to treat neurological diseases and brain tumors.





Autor: Linan Liu, Mark A. Eckert, Hamidreza Riazifar, Dong-Ku Kang, Dritan Agalliu, and Weian Zhao

Fuente: https://www.hindawi.com/



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