Pseudoalleles and gene complexes: the search for the elusive link between genome structure and gene functionReportar como inadecuado




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1 La République des savoirs : Lettres, Sciences, Philosophie

Abstract : After their discovery in the first decades of the XX th century, pseudoalleles generated much interest among geneticists: they apparently violated the conception of the genome as a collection of independent genes elaborated by Thomas Morgan-s group.
Their history is rich, complex, and deserves more than one short contribution.
I will focus on two issues: the way the phenomenon of pseudoallelism suggested that the genome was more than a simple addition of independent genes, and the connection established between the formation of pseudoalleles during evolution and their functional roles.
I will successively consider the first explanations for the origin of pseudoalleles elaborated in the mid-1930s, the metabolic-developmental sequential model proposed by Ed Lewis in the 1950s, the disappointments encountered with the T-complex in the 1970s, and the fading of the previous models after the molecular characterization of the pseudoallelic gene complexes in the 1980s.
Genomes are more than collections of genes, but their structures are the result of a complex evolutionary history that leaves no place for simplistic models.


Keywords : gene complexes pseudoalleles organization of the genome gene duplication





Autor: Michel Morange -

Fuente: https://hal.archives-ouvertes.fr/



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