The Efficacy and Immunomodulatory Effects of Ulinastatin and Thymosin α1 for Sepsis: A Systematic Review and Meta-AnalysisReport as inadecuate

The Efficacy and Immunomodulatory Effects of Ulinastatin and Thymosin α1 for Sepsis: A Systematic Review and Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2016 2016, Article ID 9508493, 8 pages -

Review ArticleFirst People’s Hospital of Foshan, Critical Care Department, Foshan 528000, China

Received 20 September 2015; Revised 13 March 2016; Accepted 5 April 2016

Academic Editor: Sohini Sengupta

Copyright © 2016 Feng Yun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To systematically review the efficacy and potential immunomodulatory effect of ulinastatin combined with thymosin α1 UTI for sepsis. Design. A systematic review and meta-analysis of randomized controlled trials RCTs. Data Sources. The following databases: PubMed, Embase, and Cochrane Central were searched to identify related clinical trials. The search terms were -ulinastatin- -thymosin-, and -sepsis-. Results. Six RCTs, 944 septic patients in total, were included in this meta-analysis. The result shows UTI increased the 28-day survival rate of septic patients, odds ratio OR = 2.01, 95% CI 1.53, 2.64. After the treatment with UTI, the APACHE II score four studies dropped 4.72 further, mean = −4.72, 95% CI −6.54, −2.91 . The mean time of ICU stay four studies in UTI group decreased 3.03 days further, mean = −3.03 −6.99, 0.95 , and mechanical ventilation time four studies decreased 2.05 days, mean = −1.81 −2.96, −0.66 . With the treatment of UTI, CD4+T cells raised 5.13%, mean = 5.13, 95% CI 2.75, 7.50 ; there was no significant change in CD8+T cells, mean = −0.74 −2.93, 1.45 . Conclusion. According to this meta-analysis, with the treatment of UTI, the short-term survival rate of septic patients was increased and the illness severity was alleviated. ICU stay and mechanical ventilation time were effectively shortened. The beneficial effect of UTI might be due to the potential immunomodulatory effects of these two drugs.

Author: Feng Yun Wang, Bin Fang, Xin Hua Qiang, Tie Ou Yu, Jia Rong Zhong, Jun Cao, and Li Xin Zhou



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