Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast IranReport as inadecuate




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The Scientific World JournalVolume 2012 2012, Article ID 950801, 5 pages

Clinical Study

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43463, Iran

Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 98167-43463, Iran

Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Science, Zahedan 98167-43463, Iran

Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43463, Iran

Received 4 June 2012; Accepted 5 September 2012

Academic Editors: S. K. Behura, H. Schwarzenbach, and A. Toulouse

Copyright © 2012 Gholamreza Bahari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tuberculosis TB is a major cause of morbidity and mortality worldwide. IRGM1 is an important protein in the innate immune response against intracellular pathogens by regulating autophagy. Polymorphisms in the IRGM genes are known to influence expression levels and may be associated with outcome of infections. This case-control study was done on 150 patients with PTB and 150 healthy subjects to determine whether the IRGM polymorphisms at positions −1208 A-G rs4958842, −1161 C-T rs4958843, and −947 C-T rs4958846 were associated with PTB. The polymorphisms were determined using tetra-amplification refractory mutation system-PCR T-ARMS-PCR. The results showed that the IRGM −1161 C-T and −947 C-T polymorphisms were associated with decreased susceptibility to PTB OR = 0.06, 95% CI = 0.03–0.13, P < 0.001 and OR = 0.27; 95% CI = 0.013–0.55, P < 0.001, resp

No significant difference was found among the groups regarding −1208 A-G polymorphism. In conclusion we found that the IRGM −1161 C-T and −947 C-T polymorphisms but not −1208 A-G polymorphism provide relative protection against PTB in a sample of Iranian population.





Author: Gholamreza Bahari, Mohammad Hashemi, Mohsen Taheri, Mohammad Naderi, Ebrahim Eskandari-Nasab, and Mahdi Atabaki

Source: https://www.hindawi.com/



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