Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in RatsReport as inadecuate




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Journal of Toxicology - Volume 2016 2016, Article ID 9507563, 9 pages -

Research Article

Department of Pharmacology, Faculty of Medicine, El-Minia University, El-Minia 61111, Egypt

Department of Histology, Faculty of Medicine, El-Minia University, El-Minia 61111, Egypt

Received 24 October 2015; Revised 21 December 2015; Accepted 28 December 2015

Academic Editor: Maria Teresa Colomina

Copyright © 2016 Marwa M. M. Refaie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nephrotoxicity is one of the limiting factors for using doxorubicin DOX. Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein DIA on DOX-induced nephrotoxicity. DIA 25 and 50 mg-kg-day was administered orally to rats for 15 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of DOX 15 mg-kg at the 11th day. We measured levels of serum urea, creatinine, renal reduced glutathione GSH, malondialdehyde MDA, total nitrites NOx, catalase, and superoxide dismutase SOD. In addition, caspase-3, tumor necrosis factor alpha TNFα, nuclear factor kappa B NFκB expressions, and renal histopathology were assessed. Our results showed that DOX-induced nephrotoxicity was ameliorated or reduced by both doses of DIA, but diacerein high dose DHD showed more improvement than diacerein low dose DLD. This protective effect was manifested by significant improvement in all measured parameters compared to DOX treated group by using DHD. DLD showed significant improvement of creatinine, MDA, NOx, GSH, histopathology, and immunohistochemical parameters compared to DOX treated group.





Author: Marwa M. M. Refaie, Entesar F. Amin, Nashwa F. El-Tahawy, and Aly M. Abdelrahman

Source: https://www.hindawi.com/



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